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Related Experiment Videos

Alzheimer's disease.

C G Gottfries

    Gerontology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Alzheimer's disease and senile dementia involve severe brain neurotransmitter disturbances. Current treatments substituting these systems show limited success, suggesting complex underlying causes.

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    Area of Science:

    • Neuroscience
    • Neuropathology
    • Biochemistry

    Background:

    • Alzheimer's disease and senile dementia are primary degenerative brain disorders.
    • Distinguished by age of onset (before or after 65), they share similar neuropathological findings.
    • Biochemical studies reveal significant neurotransmitter system disturbances in affected brains.

    Purpose of the Study:

    • To investigate the biochemical basis of Alzheimer's disease and senile dementia.
    • To examine the role of various neurotransmitter systems in these conditions.
    • To evaluate the efficacy of current treatment strategies.

    Main Methods:

    • Biochemical investigations of brain neurotransmitter systems.
    • Analysis of neuropathological findings.

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  • Review of pharmacological treatment trials.

    • Main Results:

    • Extensive and severe disturbances observed across multiple neurotransmitter systems, including acetylcholinergic, monoaminergic, GABA-ergic, and neuropeptidergic.
    • The acetylcholinergic system is notably damaged, but other systems are also implicated.
    • Pharmacological substitution trials for failing systems have yielded limited success.

    Conclusions:

    • Neurotransmitter system derangement in Alzheimer's disease and senile dementia suggests an etiology beyond the transmitter level.
    • Disturbed neurotransmitters are likely pathogenic.
    • Current therapeutic approaches targeting neurotransmitter substitution require further development due to limited efficacy.