[Validation of interaction databases in psychopharmacotherapy].
1Vitos Klinik Eichberg, Kloster-Eberbach-Str.4, 65346, Eltville, Deutschland. martina.hahn@vitos-rheingau.de.
Der Nervenarzt
|July 26, 2017
Summary
This study validated German drug interaction databases, finding MediQ performed best but requires improvement in hit rates for enhanced drug therapy safety.
Area of Science:
- Pharmacology
- Drug Safety
- Health Informatics
Background:
- Drug-drug interaction (DDI) databases are crucial for managing polypharmacy and improving patient safety.
- Existing DDIs databases vary in effectiveness, necessitating clear validation studies.
- No prior validation of German-specific DDI databases existed.
Purpose of the Study:
- To validate German drug interaction databases.
- To assess databases on DDI hit rate, mechanism accuracy, clinical advice, reference quality, and severity scoring.
- To identify the most reliable database for clinical use.
Main Methods:
- Evaluated 36 recent drug interactions (3-5 years) across five German databases.
- Assessed databases for accuracy of interaction mechanisms, provision of clinical advice, citation of primary literature, and interaction severity.
- Quantified the number of correct 'hits' for each database.
Main Results:
- All evaluated databases exhibited limitations in accurately identifying drug interactions, with a maximum hit rate of 67.7%.
- MediQ achieved the highest overall score (104/180 points), followed by PsiacOnline (83 points).
- Other databases, arznei-telegramm®, ifap index®, and ABDA-database, scored lower, indicating significant room for improvement.
Conclusions:
- MediQ demonstrated superior performance among the validated German drug interaction databases.
- Despite its leading position, MediQ requires enhancements in its hit rate to ensure user reliability.
- Improving database accuracy is essential for increasing drug therapy safety in clinical practice.
More Related Videos
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
16.8K
06:12Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
Published on: February 12, 2020
7.4K
Related Concept Videos
01:28Drug Therapy
322
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
322
01:30Quantitative Aspects of Drug-Receptor Interaction
1.9K
The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
1.9K
01:25Pharmacokinetics: Drug–Drug Interactions
532
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
532
01:29Therapeutic Drug Monitoring: Affecting Factors
283
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
283
01:30Drug toxicity: Drug–Drug Interaction
80
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
80
01:26Psychosis: Goals of Pharmacotherapy
639
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
639