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Related Experiment Video

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Brain relaxometry after macrocyclic Gd-based contrast agent.

Andreas Müller1, Alina Jurcoane1, Burkhard Mädler2

  • 1Neuroradiology, Department of Radiology, University Hospital Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.

Clinical Neuroradiology
|July 26, 2017
PubMed
Summary
This summary is machine-generated.

Serial administration of macrocyclic gadobutrol contrast agent did not alter quantitative T1 (qT1) relaxation time ratios in deep grey matter. T1-weighted signal intensity ratios were negatively affected, but not T2 relaxation time ratios.

Keywords:
Cerebral gadolinium depositionsDentate nucleusMacrocyclic contrast agentT1 relaxometryT1-weighted signal intensity

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Area of Science:

  • Radiology
  • Neuroimaging
  • Medical Physics

Background:

  • Gadolinium-based contrast agents (GBCAs) are widely used in MRI.
  • Macrocyclic GBCAs are generally considered safer due to lower gadolinium retention.
  • Long-term effects of serial GBCA administration on brain tissue are an area of ongoing research.

Purpose of the Study:

  • To evaluate the impact of repeated macrocyclic gadobutrol administration on T1-weighted (T1w) signal intensity (SI) and quantitative T1 (qT1) relaxometry in deep grey matter.
  • To assess changes in T1w SI and qT1 ratios relative to white matter and pons over time in glioblastoma patients.

Main Methods:

  • 17 glioblastoma patients underwent serial 3.0T MRI scans post-resection.
  • T1w SI, quantitative T1 (qT1), and quantitative T2 (qT2) relaxation times were measured as ratios in deep grey matter nuclei.
  • Ratios were analyzed over an average of 8 scans per patient using paired t-tests and multiple regression.

Main Results:

  • Ratios of T1w SI, qT1, and qT2 remained stable over time and did not correlate with the number of gadobutrol administrations.
  • Multivariate regression revealed no significant effect of gadobutrol on qT1 or qT2 ratios, but a negative effect on T1w SI ratios.
  • Patient age negatively influenced the qT1 ratio, while gender had no impact.

Conclusions:

  • Multiple administrations of macrocyclic gadobutrol did not alter T1 relaxation time ratios in deep grey matter structures.
  • While T1w SI ratios showed a negative effect, quantitative T1 relaxometry appears robust to serial macrocyclic contrast agent administration in this cohort.