Related Experiment Video

Updated: Feb 26, 2026

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
06:02

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers

Published on: February 20, 2017

8.0K

Regulation of paclitaxel activity by microtubule-associated proteins in cancer chemotherapy

Xingjuan Shi1, Xiaoou Sun2

  • 1Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. xingjuanshi@seu.edu.cn.

Cancer Chemotherapy and Pharmacology
|July 26, 2017
PubMed

Insights

Microtubule-associated proteins impact cancer treatment efficacy. Understanding their role, especially centrosomal proteins, can improve paclitaxel chemotherapy and overcome drug resistance.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Biochemistry

Background:

  • Microtubules are crucial cytoskeleton components involved in cell division and migration.
  • Their dynamics are regulated by microtubule-associated proteins (MAPs).
  • Cancer arises from dysregulated cellular processes, including microtubule dynamics.

Purpose of the Study:

  • To review the role of MAPs in regulating paclitaxel sensitivity in various cancers.
  • To highlight the specific influence of centrosomal proteins on paclitaxel resistance.
  • To provide insights for optimizing cancer chemotherapeutic strategies.

Main Methods:

  • Literature review of studies on MAPs and paclitaxel resistance.
  • Analysis of the mechanisms by which MAPs modulate microtubule dynamics.
  • Focus on centrosomal proteins and their impact on drug response.

Main Results:

  • MAPs significantly influence patient response to paclitaxel therapy.
  • Specific MAPs can either enhance or reduce sensitivity to paclitaxel.
  • Centrosomal proteins play a key role in the development of paclitaxel resistance.

Conclusions:

  • MAPs are critical regulators of paclitaxel efficacy in cancer treatment.
  • Targeting specific MAPs, particularly centrosomal proteins, may overcome paclitaxel resistance.
  • Further understanding of MAPs can lead to personalized and more effective chemotherapy regimens.
Keywords:
Cancer chemotherapyCentrosomal proteinsMicrotubule-associated proteinsMicrotubulesPaclitaxel

More Related Videos

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

14.1K
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

10.6K

Related Concept Videos

Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.8K
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
4.1K
Destabilization of Microtubules01:45

Destabilization of Microtubules

The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...
3.8K
Microtubule Associated Proteins (MAPs)01:42

Microtubule Associated Proteins (MAPs)

Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
6.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Microtubule Instability02:17

Microtubule Instability

Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
6.3K