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Updated: Feb 26, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
Published on: August 16, 2021
The last frontier: transcatheter devices for percutaneous or minimally invasive treatment of chronic heart failure
V J Nijenhuis1, L Sanchis2, J A S van der Heyden3
1Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands. v.nijenhuis@antoniusziekenhuis.nl.
Insights
New transcatheter devices offer novel minimally invasive treatment options for heart failure patients. Early studies show promise for improving outcomes through left ventricular remodelling and pressure reduction, but more clinical evidence is needed.
Area of Science:
- Cardiology
- Medical Devices
- Interventional Cardiology
Background:
- Heart failure affects a significant portion of the population, with high morbidity and mortality rates.
- Current treatments, including medications and device therapies, have limitations.
- Minimally invasive and transcatheter devices are emerging as promising alternatives.
Purpose of the Study:
- To review novel transcatheter devices for treating chronic heart failure.
- To focus on interventions targeting left ventricular remodelling, left atrial pressure, tricuspid regurgitation, and neuromodulation.
- To highlight the early stage of clinical evaluation for these new devices.
Main Methods:
- Review of current literature on transcatheter devices for heart failure.
- Focus on devices addressing specific pathophysiological mechanisms.
- Analysis of early feasibility and safety studies.
Main Results:
- Rapid development and clinical adoption of transcatheter devices for valvular heart disease.
- Emerging transcatheter interventions for chronic heart failure are targeting diverse pathophysiological pathways.
- Early clinical evaluations indicate feasibility and safety for novel devices.
Conclusions:
- Transcatheter device therapy is rapidly evolving for heart failure management.
- Further clinical trials are essential to establish the efficacy and long-term benefits of these innovative treatments.
- These devices represent a significant advancement in the minimally invasive treatment of heart failure.
Abstract:
Heart failure has a high prevalence in the general population. Morbidity and mortality of heart failure patients remain high, despite improvements in drug therapy, implantable cardioverter-defibrillators and cardiac resynchronisation therapy. New transcatheter implantable devices have been developed to improve the treatment of heart failure. There has been a rapid development of minimally invasive or transcatheter devices used in the treatment of heart failure associated with aortic and mitral valve disease and these devices are being incorporated into routine clinical practice at a fast rate. Several other new transcatheter structural heart interventions for chronic heart failure aimed at a variety of pathophysiologic approaches are currently being developed. In this review, we focus on devices used in the treatment of chronic heart failure by means of left ventricular remodelling, left atrial pressure reduction, tricuspid regurgitation reduction and neuromodulation. The clinical evaluations of these devices are early-stage evaluations of initial feasibility and safety studies and additional clinical evidence needs to be gathered in appropriately designed clinical trials.
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