Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

9.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.3K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

10.4K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
10.4K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.2K
Production of Formed Elements01:34

Production of Formed Elements

5.0K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
5.0K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.0K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

4.1K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic interference with SARS-CoV-2 replication by molnupiravir-derived N<sup>4</sup>-hydroxycytidine and inhibitors of CTP synthetase in cell culture.

Virology·2025
Same author

Hematopoietic stem cells in human fetal liver selectively express CD49f.

Experimental hematology·2025
Same author

Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction.

Blood·2025
Same author

Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines.

Leukemia·2024
Same author

Dependence of human cell survival and proliferation on the CASP3 prodomain.

Cell death discovery·2024
Same author

Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance.

CA: a cancer journal for clinicians·2024
Same journal

Patient-derived organoids in hematologic malignancies: Fidelity and translation beyond animals.

Trends in cancer·2026
Same journal

Precision neuro-oncology for children: Time to gear up!

Trends in cancer·2026
Same journal

Multi-omics analysis of extracellular vesicle cargo in cancer.

Trends in cancer·2026
Same journal

An immunological panacea for cancer-related cachexia.

Trends in cancer·2026
Same journal

Beyond one gene, one target: Next-generation precision oncology.

Trends in cancer·2026
Same journal

Horizontal mitochondrial transfer and the tug-of-war between cancer cells and immune cells.

Trends in cancer·2026
See all related articles

Related Experiment Video

Updated: Feb 26, 2026

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

16.0K

Modeling Normal and Disordered Human Hematopoiesis.

Philip A Beer1, Connie J Eaves2

  • 1Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, V5Z 1L3, Canada; Current address: 14M Genomics, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Trends in Cancer
|July 26, 2017
PubMed
Summary
This summary is machine-generated.

Mice are a common model for human blood cell development, but significant genetic and cellular differences exist. Advances in human cell manipulation suggest a future shift towards direct study of human hematopoiesis.

More Related Videos

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

4.0K
Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

1.0K

Related Experiment Videos

Last Updated: Feb 26, 2026

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

16.0K
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

4.0K
Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

1.0K

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Genetics

Background:

  • Mice are widely used to study human blood formation due to genetic accessibility.
  • However, critical differences in gene function and mutation effects exist between mouse and human hematopoiesis.
  • Existing mouse models do not fully recapitulate human blood development.

Purpose of the Study:

  • To review the limitations of mouse models for human hematopoiesis.
  • To highlight advancements enabling direct study of human hematopoietic cells.
  • To discuss the evolving landscape of hematopoiesis research.

Main Methods:

  • Comparative analysis of mouse and human hematopoietic systems.
  • Review of genetic manipulation techniques in mouse and human cells.
  • Assessment of progress in humanized mouse models and human cell culture.

Main Results:

  • Significant discrepancies identified in gene product roles and mutation impacts between mouse and human hematopoiesis.
  • Increasingly permissive methods for human hematopoietic cell generation and propagation.
  • Rapid advancements in developing humanized mouse models.

Conclusions:

  • The mouse model has incomplete fidelity for studying human hematopoiesis.
  • Technological progress supports a paradigm shift towards direct investigation of human hematopoietic cells.
  • Future research will likely focus more on human-specific studies.