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Updated: Feb 26, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
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Published on: October 5, 2012

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Targeting BCL-2-like Proteins to Kill Cancer Cells

Suzanne Cory1, Andrew W Roberts2, Peter M Colman1

  • 1The Walter and Eliza Hall Institute of Medical Research, Victoria 3052, Australia; Department of Medical Biology, University of Melbourne, Victoria 3052, Australia.

Trends in Cancer
|July 26, 2017
PubMed
Summary

BH3 mimetics are a new class of cancer drugs targeting the B cell lymphoma (BCL)-2 family to restore apoptosis. Venetoclax (ABT-199) shows promise, with emerging drugs targeting MCL-1 for broader cancer therapy.

Keywords:
BCL-2 protein familyBH3 mimetic drugsapoptosischronic lymphocytic leukemiadrug developmentmitochondrial membrane

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