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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
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Cells of the Innate Immune Response

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
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Cytotoxic T Cells-mediated Immune Response

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Tumor Immunotherapy

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Related Experiment Video

Updated: Feb 26, 2026

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment

Published on: August 3, 2018

Immunity Gone Astray - NETs in Cancer.

Jessica Cedervall¹, Anna-Karin Olsson¹

¹Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Biomedical Center, Box 582, SE-75123 Uppsala, Sweden.

Trends in Cancer

|July 26, 2017

Summary

Neutrophil extracellular traps (NETs) drive cancer pathologies like metastasis and thrombosis. Targeting tumor-induced NET formation presents a promising therapeutic strategy in oncology.

Keywords:

NETs cancer coagulation inflammation metastasis neutrophil extracellular traps

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Last Updated: Feb 26, 2026

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment

Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment

Published on: August 3, 2018

Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues

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Published on: August 18, 2023

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Published on: November 4, 2022

Area of Science:

Oncology
Immunology
Pathology

Background:

Neutrophil extracellular traps (NETs) are implicated in cancer progression.
NETs contribute to metastasis, thrombosis, and organ dysfunction in preclinical cancer models.

Purpose of the Study:

To review the role of NETs in human cancers.
To explore tumor-induced NET formation as a therapeutic target.

Main Methods:

Literature review of recent discoveries on NETs in human cancers.

Main Results:

NETs are involved in various human cancer pathologies.
Tumor-induced NET formation is a significant factor in cancer progression.

Conclusions:

NETs play a critical role in cancer-associated pathologies.
Targeting NET formation offers a potential therapeutic avenue in oncology.