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Filling the Gap on Caveolin-1 in Liver Carcinogenesis
Manuel A Fernandez-Rojo1, Grant A Ramm1
1QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Faculty of Medicine and Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Trends in Cancer
|July 26, 2017
Abstract:
Caveolin-1 (CAV1) has emerged as a promoter of proliferation, metastasis, and chemoresistance in hepatoma cells, as well as a marker of poor prognosis in liver cancer. We discuss here current knowledge and future approaches to elucidating the molecular mechanisms underlying CAV1 action during hepatocarcinogenesis and evaluate its potential use in clinical therapies.
