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Causal role for the subthalamic nucleus in interrupting behavior.

Kathryn H Fife1, Navarre A Gutierrez-Reed2, Vivien Zell3

  • 1Neurosciences Graduate Program, University of California, San Diego, San Diego, United States.

Elife
|July 26, 2017
PubMed
Summary

The subthalamic nucleus (STN) is crucial for stopping behavior. Activating the STN interrupts actions, while inhibiting it reduces the impact of surprise, confirming its causal role in behavioral suppression.

Keywords:
STNmouseneuroscienceoptogeneticsresponse inhibitionstoppingsubthalamic nucleusvesicular glutamate transporter 2

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Optogenetics

Background:

  • Stopping or pausing is a fundamental behavior in response to various stimuli.
  • The subthalamic nucleus (STN) is known to be activated during stopping behaviors, but its causal role is not well-established.

Purpose of the Study:

  • To investigate the causal role of the subthalamic nucleus (STN) in behavioral response suppression using optogenetics in mice.

Main Methods:

  • Optogenetic activation and inhibition of mouse STN and its projection neurons.
  • Assessing the effect of STN manipulation on self-initiated licking behavior.
  • Utilizing a surprise-induced licking interruption assay.

Main Results:

  • Optogenetic stimulation of the STN successfully excited its projection targets.
  • Brief activation of STN projection neurons was sufficient to pause ongoing licking behavior.
  • Inhibition of the STN reduced the disruptive effect of surprise on licking behavior.

Conclusions:

  • The subthalamic nucleus (STN) plays a necessary and sufficient causal role in interrupting ongoing behaviors.
  • STN activation is sufficient to suppress behavior, and STN inhibition impairs the ability to suppress behavior in response to external cues like surprise.