Related Experiment Video
Updated: Feb 25, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
A Review of the Epigenetic Contributions to Endometriosis
Frances W Grimstad1, Alan Decherney
1*Department of Obstetrics and Gynecology, University of Kansas Medical Center, Lawrence, Kansas †Reproductive and Adult Endocrinology/Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health, Bethesda, Maryland.
Abstract:
Epigenetic influences have been postulated to affect the course of endometriosis. DNA methyltransferases, estrogen and progesterone receptors, micro-RNAs, and histone deacetylators, have shown differential expression in endometriosis compared with normal endometrium. Others such as aromatase, Steroid Factor-1, COX-2, and Homeobox A10 also have epigenetic modifications in endometriosis. Limitations in this area of research include heterogeneity in study design, patient populations, and methods of analysis. Larger, controlled studies are needed. Future targeted uses of this work may include using methylomes to noninvasively diagnose endometriosis, or targeting histone-deacetylase inhibitors for treatment.
More Related Videos
07:20Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
Published on: December 21, 2012
07:12A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
Related Concept Videos
Oogenesis
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...