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Related Experiment Videos

Serum relaxin in pregnancy.

A H MacLennan, R Nicolson, R C Green

    Lancet (London, England)
    |August 2, 1986
    PubMed
    Summary

    Serum relaxin levels decrease in late pregnancy but rise during labor. Lower relaxin may indicate preterm labor risk, while higher levels are seen in twin pregnancies, suggesting relaxin

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    Area of Science:

    • Reproductive Endocrinology
    • Maternal-Fetal Medicine
    • Hormonal Regulation of Pregnancy

    Background:

    • Serum relaxin is a key hormone in pregnancy.
    • Its precise role in labor onset and progression requires further elucidation.

    Purpose of the Study:

    • To investigate serum relaxin immunoactivity across different stages of pregnancy.
    • To correlate relaxin levels with spontaneous labor, preterm labor, and twin pregnancies.

    Main Methods:

    • Cross-sectional study of 302 normal singleton pregnancies.
    • Radioimmunoassay technique used to measure serum relaxin levels.
    • Comparison of relaxin concentrations in early, mid, and third trimesters, during labor, and postpartum.

    Main Results:

    • Third-trimester relaxin levels were lower than in early/mid-pregnancy.
    • Significantly lower relaxin at term in women with spontaneous labor onset.
    • Highest relaxin levels observed during labor, decreasing postpartum.
    • Elevated third-trimester relaxin in twin pregnancies compared to singletons.
    • Declining, low relaxin levels noted in a patient with preterm delivery.

    Conclusions:

    • Serum relaxin may play a role in maintaining myometrial quiescence.
    • Relaxin facilitates uterine growth and cervical ripening.
    • Relaxin levels can potentially predict preterm labor risk and differ in multiple gestations.

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