Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report

The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction.

In this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal.

Clozapine associated eosinophilia should be suspected in the setting of eosinophilic infiltration of multiple organs.