Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sickle cell nephropathy. Clinical manifestations and new mechanisms involved in kidney injury.

Nefrologia·2022

Same author

Use of intravenous iron in critically ill patients with anemia.

Medicina clinica·2017

Same author

On the safety of intravenous iron formulations.

Medicina clinica·2017

Same author

[Treatment of perioperative anemia in hip fracture].

Medicina clinica·2015

Same author

[Thoughts about the usefulness of the preoperatory administration of intravenous iron in hip fracture surgery].

Medicina clinica·2013

Same author

[Intravenous administration of tranexamic acid to decrease bleeding and transfusion in knee and hip prosthetic surgery: is it safe and cost-effective?].

Medicina clinica·2013

Search research articles

Related Experiment Video

Updated: Feb 25, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

Anaemia in the elderly.

Susana Gómez Ramírez¹, Ángel Francisco Remacha Sevilla², Manuel Muñoz Gómez³

¹Anemia Working Group España (AWGE); Unidad de Gestión Clínica de Medicina Interna, Hospital Clínico Virgen de la Victoria, Málaga, España.

Medicina Clinica

|July 27, 2017

Summary

Anemia is common in older adults, increasing health risks. Treating anemia can improve physical function and capacity in elderly patients.

Keywords:

Anaemia Ancianos Anemia Anemia indeterminada Deficiencias nutricionales Elderly Eritropoyetina Erythropoietin Indeterminate anaemia Inflamación Inflammation Nutritional deficiencies

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Related Experiment Videos

Last Updated: Feb 25, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Area of Science:

Geriatrics
Hematology
Internal Medicine

Background:

Anemia is prevalent in the elderly, linked to adverse outcomes like cognitive decline and mortality.
The causal role of anemia versus its status as a marker of poor health is unclear.
Correcting anemia may enhance physical and functional capabilities in older individuals.

Purpose of the Study:

To emphasize the importance of detecting, classifying, and treating anemia in the elderly.
To outline diagnostic and therapeutic strategies for elderly patients with anemia.

Main Methods:

Utilizing medical history and physical examination to determine anemia etiology.
Employing a diagnostic algorithm based on laboratory data for classification.
Guiding treatment based on anemia classification and underlying causes.

Main Results:

Identified nutritional deficiencies and chronic disease (with or without kidney failure) as primary causes.
Acknowledged indeterminate origins in some cases.
Established treatment mainstays including iron, maturation factors, and erythropoiesis-stimulating agents.

Conclusions:

Anemia management is a critical health system priority for the elderly.
A systematic approach to diagnosis and treatment is essential.
Red blood cell transfusions are indicated only for severe anemia cases.