Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Flow02:39

Gene Flow

38.3K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
38.3K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

64.9K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
64.9K
Genetic Drift03:33

Genetic Drift

44.4K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
44.4K
Horizontal Gene Transfer01:27

Horizontal Gene Transfer

2.5K
Horizontal gene transfer (HGT) is a process where genetic material moves between organisms within the same generation, unlike vertical gene transfer, which occurs from parent to offspring. HGT plays a crucial role in microbial evolution, adaptation, and survival, particularly in shared environments like the human gut.Mobile genetic elements such as plasmids, prophages, integrons, insertion sequences, and transposons facilitate this process. HGT occurs through three primary mechanisms:...
2.5K
Genetics of Speciation02:16

Genetics of Speciation

22.2K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
22.2K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

8.1K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of complications and comorbidities associated with obesity: a health insurance claims analysis.

BMC public health·2025
Same author

Lineage-specific patterns in the Moraceae family allow identification of convergent P450 enzymes involved in furanocoumarin biosynthesis.

The New phytologist·2025
Same author

Transcriptomic resources for Bagrada hilaris (Burmeister), a widespread invasive pest of Brassicales.

PloS one·2024
Same author

Genomic, transcriptomic, and metabolomic analyses reveal convergent evolution of oxime biosynthesis in Darwin's orchid.

Molecular plant·2024
Same author

Sequence diversity in the monooxygenases involved in oxime production in plant defense and signaling: a conservative revision in the nomenclature of the highly complex CYP79 family.

The Plant journal : for cell and molecular biology·2024
Same author

Cytochromes P450 evolution in the plant terrestrialization context.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2024

Related Experiment Video

Updated: Feb 25, 2026

Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive
10:21

Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive

Published on: July 4, 2007

11.2K

Spatial gene drives and pushed genetic waves.

Hidenori Tanaka1,2, Howard A Stone3, David R Nelson1,4,5

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; tanaka@g.harvard.edu drnelson@fas.harvard.edu.

Proceedings of the National Academy of Sciences of the United States of America
|July 27, 2017
PubMed
Summary

Gene drives can alter wild-type alleles but require specific conditions (0.5 < s < 0.697) to spread safely. A "critical propagule" threshold prevents accidental release, safeguarding ecosystems from irreversible damage.

Keywords:
Fisher wavebistable wavegene drive

More Related Videos

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes
07:45

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

3.2K
Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes
09:41

Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes

Published on: September 15, 2023

1.3K

Related Experiment Videos

Last Updated: Feb 25, 2026

Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive
10:21

Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive

Published on: July 4, 2007

11.2K
Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes
07:45

Small-Cage Laboratory Trials of Genetically-Engineered Anopheline Mosquitoes

Published on: May 1, 2021

3.2K
Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes
09:41

Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes

Published on: September 15, 2023

1.3K

Area of Science:

  • Ecology
  • Genetics
  • Mathematical Biology

Background:

  • Gene drives offer powerful tools for modifying wild-type alleles in populations.
  • Uncontrolled release of gene drives poses significant ecological risks due to irreversible ecosystem damage.

Purpose of the Study:

  • To investigate the spatiotemporal dynamics of gene drive spread in diploid organisms.
  • To identify conditions for safe and controlled gene drive deployment, preventing accidental ecological harm.

Main Methods:

  • Utilized a reaction-diffusion model for sexually reproducing diploid organisms.
  • Applied mathematical methods developed by Barton and collaborators to analyze gene drive dynamics.
  • Modeled the spread of a gene drive allele with a selective disadvantage (s > 0).

Main Results:

  • Identified a narrow selective disadvantage range (0.5 < s < 0.697) for socially responsible gene drives, termed the "pushed wave" regime.
  • Demonstrated that gene drive spread is contingent upon exceeding a "critical propagule" initial frequency threshold, acting as a safeguard.
  • Showed that "sensitizing drives" can halt spatial spread and that imperfect barriers can stop gene drives in 2D.

Conclusions:

  • Safe gene drive implementation necessitates precise control over allele frequency and selective disadvantage.
  • The "critical propagule" mechanism provides a crucial safeguard against premature or accidental gene drive release.
  • Gene drive containment strategies, including sensitization and barrier use, are viable for ecological risk management.