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Related Experiment Videos

Ranking of laboratory tests by consensus analysis.

B S Bull, W C Levy, J C Westengard

    Lancet (London, England)
    |August 16, 1986
    PubMed
    Summary

    Consensus analysis, a new method for evaluating laboratory tests, identified plasma viscosity and erythrocyte sedimentation rate as top indicators for monitoring inflammatory disease. This technique can improve test selection and the development of more sensitive diagnostic tools.

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    Area of Science:

    • Clinical chemistry
    • Immunology
    • Rheumatology

    Background:

    • Laboratory tests are crucial for monitoring inflammatory diseases.
    • Current monitoring methods may lack optimal sensitivity or specificity.
    • Cost-effectiveness in laboratory diagnostics is a significant consideration.

    Purpose of the Study:

    • To introduce and evaluate a novel analytical technique, consensus analysis.
    • To assess the performance of common laboratory tests for inflammatory disease monitoring.
    • To identify the most effective tests for tracking acute and chronic inflammatory phases.

    Main Methods:

    • Developed a new analytical technique: consensus analysis.
    • Applied consensus analysis to data from thirty-one laboratory tests.

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  • Monitored seventeen rheumatoid arthritis patients over seven months with monthly tests.

    • Main Results:

    • Consensus analysis ranked plasma viscosity and erythrocyte sedimentation rate as the top-performing tests.
    • Acute-phase serum protein orosomucoid was ranked third.
    • The technique demonstrated potential for identifying the most useful diagnostic tests.

    Conclusions:

    • Consensus analysis is a valuable tool for assessing laboratory test performance in inflammatory disease.
    • The method can guide the selection of cost-effective and informative tests.
    • This approach may aid in designing more sensitive and specific future diagnostic assays.