Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The management of primary hyperparathyroidism.

S Posen, P Clifton-Bligh, R S Mason

    Australian and New Zealand Journal of Medicine
    |February 1, 1979
    PubMed
    Summary

    This paper reviews the current state of managing primary hyperparathyroidism. It highlights that while serum parathyroid hormone assays have made diagnosis easier, challenges remain in deciding who should have surgery and how to locate the affected glands. The authors suggest that medical treatment is an option for patients who cannot undergo surgery. However, no single diagnostic test has been proven to reliably locate parathyroid lesions. The paper concludes that more research is needed to improve diagnostic and treatment strategies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Search for Dark Photons with Superconducting Radio Frequency Cavities.

    Physical review letters·2023
    Same author

    Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone.

    Calcified tissue international·2023
    Same author

    Field-Enhanced Superconductivity in High-Frequency Niobium Accelerating Cavities.

    Physical review letters·2018
    Same author

    1,25-Dihydroxycholecalciferol (calcitriol) modifies uptake and release of 25-hydroxycholecalciferol in skeletal muscle cells in culture.

    The Journal of steroid biochemistry and molecular biology·2017
    Same author

    Sunlight exposure is just one of the factors which influence vitamin D status.

    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2017
    Same author

    The effect of parathyroid hormone on the uptake and retention of 25-hydroxyvitamin D in skeletal muscle cells.

    The Journal of steroid biochemistry and molecular biology·2017

    Area of Science:

    • Endocrinology and metabolic disorders
    • Surgical decision-making in endocrine diseases
    • Diagnostic endocrinology

    Background:

    Serum parathyroid hormone assays have simplified the identification of hyperparathyroidism. Yet, challenges remain in determining which patients should undergo surgery. Prior research has established that parathyroid hormone levels are useful for diagnosis. However, the criteria for surgical candidacy remain unclear. No prior work has resolved how to best select patients for surgical intervention. The pre-operative localization of parathyroid lesions remains a challenge. Medical management is often needed for patients who cannot undergo surgery. This gap motivated further investigation into diagnostic and therapeutic strategies.

    Purpose Of The Study:

    This paper aims to clarify unresolved issues in managing primary hyperparathyroidism. The focus is on patient selection for surgery, a critical but uncertain step in treatment. The authors seek to address the diagnostic challenges in localizing parathyroid lesions. They also examine medical management options for non-surgical candidates. The motivation stems from the lack of consensus on these clinical decisions. No prior work has fully resolved these uncertainties. The study emphasizes the need for standardized approaches. It proposes to synthesize current evidence to guide clinical practice.

    Keywords:
    Hyperparathyroidism surgical criteriaParathyroid hormone testingEndocrine surgery guidelinesMedical management hyperparathyroidism

    Frequently Asked Questions

    According to the authors, serum parathyroid hormone assays are reliable for diagnosis but do not resolve surgical selection criteria.

    The authors suggest that surgical referral criteria remain inconsistent and are influenced by multiple patient-specific factors.

    The authors propose that no single diagnostic test has been universally validated for lesion localization.

    Medical management is proposed as an alternative for patients who are unsuitable for surgery.

    Related Experiment Videos

    Main Methods:

    The authors conducted a review of existing literature on primary hyperparathyroidism management. They analyzed studies focusing on surgical selection criteria. The review included pre-operative localization techniques. Medical treatment strategies were also evaluated. The synthesis of findings was based on clinical guidelines and published research. No new data collection was performed. The approach involved comparing diagnostic and therapeutic options. The goal was to identify gaps and propose practical recommendations.

    Main Results:

    The strongest finding is that serum parathyroid hormone assays are reliable for diagnosis. However, the criteria for surgical referral remain inconsistent. Pre-operative imaging techniques have variable accuracy in localizing lesions. Medical management is often used for patients ineligible for surgery. No single diagnostic test has been universally validated for lesion localization. The review suggests that surgical decision-making is influenced by multiple factors. Medical treatment outcomes vary, and long-term efficacy is not well established. These findings highlight the need for further clinical research.

    Conclusions:

    The authors propose that serum parathyroid hormone assays remain central to diagnosis. They suggest that surgical selection criteria should be individualized based on patient factors. Pre-operative localization remains a challenge with no definitive solution. Medical management is an alternative for non-surgical patients. The review does not suggest a single best practice for lesion localization. The authors emphasize the need for further research to clarify these issues. They conclude that current guidelines are insufficient for resolving all clinical uncertainties. Their findings suggest that a multidisciplinary approach is necessary.

    The authors suggest that imaging techniques have variable accuracy and lack universal validation.

    The authors propose that further research is needed to clarify surgical selection and diagnostic localization.