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Management of hyperplastic gastric polyp following upper gastrointestinal bleeding in infant with Menkes' disease

Dalia Belsha1, Priya Narula1, Arun Urs1

  • 1Dalia Belsha, Priya Narula, Arun Urs, Mike Thomson, Centre of Paediatric Gastroenterology, Sheffield Children's Hospital, Sheffield S10 2TH, United Kingdom.

World Journal of Gastrointestinal Endoscopy
|July 27, 2017
PubMed

Insights

This case study details an infant with Menkes

Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Medical Genetics

Background:

  • Menkes' disease (MD) is a rare genetic disorder affecting copper metabolism.
  • Gastrointestinal manifestations, though reported, are less common.
  • Early diagnosis and management are crucial for patient outcomes.

Observation:

  • A five-month-old infant presented with severe upper gastrointestinal bleeding (coffee ground vomiting, melaena) and anemia.
  • Endoscopic evaluation revealed a large, bleeding, trans-pyloric polyp.
  • The infant had a confirmed diagnosis of Menkes' disease.

Findings:

  • Endoscopic mucosal resection using a grasp-and-snare technique successfully removed the polyp.
  • Argon plasma coagulation achieved hemostasis, and no perforation occurred.
  • Complete excision after repeated debridement resolved bleeding without further transfusions.

Implications:

  • This case highlights a rare but significant gastrointestinal complication in Menkes' disease.
  • Advanced endoscopic techniques can effectively manage such bleeding polyps in infants.
  • Further research into GI manifestations of MD is warranted.

Keywords:
Gastric polypGastrointestinal bleedingGrasp and snare techniqueMenkes’ diseasePolypectomy

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