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TMEM39A and Human Diseases: A Brief Review
Quangdon Tran1, Jisoo Park1, Hyunji Lee1
1Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, Korea.
Toxicological Research
|July 27, 2017
Summary
Transmembrane Protein 39A (TMEM39A) is a poorly understood protein implicated in autoimmune diseases like lupus and multiple sclerosis. Further research is needed to clarify its roles in cell biology and pathology.
Area of Science:
- Molecular Biology
- Immunology
- Genetics
Background:
- Transmembrane Protein 39A (TMEM39A) belongs to the TMEM protein family, with limited current understanding.
- Previous research suggests TMEM39A's involvement as a mediator in autoimmune diseases.
- TMEM39A has been linked to systemic lupus erythematosus and multiple sclerosis across diverse populations.
Purpose of the Study:
- To review current knowledge on TMEM39A.
- To explore TMEM39A's potential functions in cell biology, physiology, and pathology.
Main Methods:
- Review of existing literature.
- Analysis of gene functioning studies, including Genome-wide association studies (GWASs).
Main Results:
- Current understanding of TMEM39A is limited, despite its association with autoimmune conditions.
- Existing studies often rely on GWASs and follow-up investigations, yielding insufficient information.
Conclusions:
- TMEM39A represents an area of significant scientific interest due to its limited characterization.
- Further investigation is warranted to elucidate TMEM39A's comprehensive biological roles and pathological implications.
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