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iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery
Lijun Ma1, Qiubing Chen1, Panpan Ma1
1Institute for Clean Energy & Advanced Materials, Faculty of Materials & Energy, Southwest University, Chongqing 400715, PR China.
Aim:
To enhance the tumor accumulation and targeted drug delivery for colon cancer therapy, iRGD peptide was introduced to the surface of PEGylated camptothecin-loaded nanoparticles (NPs).
Methods:
Cellular uptake, targeting specificity, biodistribution and antitumor capacity were evaluated.
Results:
The functionalization of iRGD facilitated tumor accumulation and cellular uptake of NPs by Colon-26 cells. Furthermore, the resultant iRGD-PEG-NPs remarkably improved the therapeutic efficacy of camptothecin in vitro and in vivo by inducing a higher degree of tumor cell apoptosis compared with PEG-NPs.
Conclusion:
iRGD-PEG-NP is a desired drug delivery system to facilitate the drug accumulation in orthotopic colon tumor tissues and further drug internalization by colon cancer cells.
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