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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Updated: Feb 25, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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[A skin lesion with ghost cells].

I M Markusse1, B Velstra, K van der Putten

  • 1Tergooi, Hilversum.

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Summary
This summary is machine-generated.

Pancreatic panniculitis is a rare condition causing painful skin nodules. It is associated with pancreatitis and characterized by fat cell necrosis in skin biopsies.

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Area of Science:

  • Dermatology
  • Gastroenterology
  • Pathology

Background:

  • Pancreatic panniculitis is an uncommon panniculitis associated with pancreatic disease.
  • It is characterized by subcutaneous fat necrosis and often presents with painful nodules on the lower extremities.

Observation:

  • An 83-year-old female patient presented with painful, erythematous nodules on her feet and legs.
  • The patient had a history of recurrent pancreatitis of unknown etiology.

Findings:

  • Skin biopsy revealed characteristic findings of fat cell necrosis with ghost cells.
  • The diagnosis of pancreatic panniculitis was confirmed based on clinical and histopathological evidence.

Implications:

  • This case highlights the importance of considering pancreatic panniculitis in patients with unexplained pancreatitis and characteristic skin lesions.
  • Early recognition and diagnosis are crucial for managing this rare condition and addressing the underlying pancreatic pathology.