Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mercury (II) Ion Sensing Through in Situ Synthesis of Gold Nanoparticles.

ACS applied nano materials·2026
Same author

Recent treatment outcomes of cervical intraepithelial neoplasia in south western Uganda: a six year retrospective study.

Gynecologic oncology reports·2026
Same author

Detection of mutant cancer-derived circRNAs in extracellular vesicles by rolling circle amplification.

Molecular therapy. Nucleic acids·2026
Same author

Hydrogel-based multiplexed high-risk human papillomavirus DNA/RNA detection for cervical cancer screening.

Biosensors & bioelectronics: X·2026
Same author

Molecular Analysis of Single Tumor-Derived Extracellular Vesicles with Improved Robustness and Accuracy.

Analytical chemistry·2026
Same author

Self-amplifying CRISPR-based one-pot ultrasensitive testing for rapid SARS-CoV-2 and its variant detection.

Biosensors & bioelectronics·2026

Related Experiment Video

Updated: Feb 25, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.9K

Novel nanosensing technologies for exosome detection and profiling.

Hyungsoon Im1, Kyungheon Lee, Ralph Weissleder

  • 1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA. hlee@mgh.harvard.edu castro.cesar@mgh.harvard.edu.

Lab on a Chip
|July 27, 2017
PubMed
Summary

Exosomes are promising cancer biomarkers found in bodily fluids. New nanotechnology sensing platforms offer sensitive detection and analysis of exosomal proteins and RNAs for improved cancer diagnosis and profiling.

More Related Videos

An Innovative Method for Exosome Quantification and Size Measurement
11:38

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

31.6K
Detection of Exosomal Biomarker by Electric Field-induced Release and Measurement EFIRM
11:02

Detection of Exosomal Biomarker by Electric Field-induced Release and Measurement EFIRM

Published on: January 23, 2015

19.0K

Related Experiment Videos

Last Updated: Feb 25, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.9K
An Innovative Method for Exosome Quantification and Size Measurement
11:38

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

31.6K
Detection of Exosomal Biomarker by Electric Field-induced Release and Measurement EFIRM
11:02

Detection of Exosomal Biomarker by Electric Field-induced Release and Measurement EFIRM

Published on: January 23, 2015

19.0K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Diagnostics

Background:

  • Exosomes are increasingly recognized as valuable cancer biomarkers due to their abundance in biofluids and stable molecular cargo.
  • Current methods for exosome quantification and molecular analysis are often complex and lack sensitivity, hindering clinical application.

Purpose of the Study:

  • To review and describe nanotechnology-based sensing platforms for exosome analysis.
  • To highlight advancements in detecting exosomal proteins and RNAs directly from clinical specimens.
  • To discuss future directions for translating these technologies into routine clinical practice.

Main Methods:

  • Review of three distinct nanotechnology sensing platforms for exosome detection.
  • Focus on platforms enabling direct analysis of exosomal proteins and RNAs.
  • Discussion of technological advancements and challenges in exosome sensing.

Main Results:

  • Nanotechnology platforms demonstrate potential for sensitive and rapid exosome quantification.
  • These platforms allow for detailed molecular profiling of exosomes, including proteins and RNA.
  • Direct analysis from clinical specimens is feasible with the reviewed technologies.

Conclusions:

  • Next-generation sensing technologies are crucial for realizing the clinical potential of exosomes.
  • Nanotechnology offers promising solutions for sensitive and reliable exosome detection and analysis.
  • Further development is needed to facilitate the clinical translation of these advanced exosome sensing platforms.