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Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization

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Multiview Hilbert transformation in full-ring transducer array-based photoacoustic computed tomography.

Lei Li¹, Liren Zhu², Yuecheng Shen³

¹Washington University in St. Louis, Department of Electrical and System Engineering, St. Louis, Missouri, United StatesbCalifornia Institute of Technology, Andrew and Peggy Cherng Department of Medical Engineering, Caltech Optical Imaging Laboratory, Pasadena, California, United States.

Journal of Biomedical Optics

|July 27, 2017

Summary

This study introduces a multiview Hilbert transformation to improve photoacoustic computed tomography (PACT) imaging. The method recovers unipolar initial pressure, resolving bipolar artifacts in small-animal imaging for clearer biological and medical interpretation.

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Area of Science:

Biomedical optics
Medical imaging
Photoacoustic imaging

Background:

Photoacoustic (PA) tomography measures optical absorption using the PA effect.
A full-ring ultrasonic transducer array-based PACT system offers high resolution for small-animal imaging.
Current PACT systems yield bipolar images due to transducer properties, hindering interpretation.

Purpose of the Study:

To develop a method for recovering unipolar initial pressure in full-ring PACT.
To address image ambiguities caused by bipolar pixel values in PACT reconstructions.
To enhance the interpretability of PACT images for biological and medical applications.

Main Methods:

Implementation of a multiview Hilbert transformation algorithm.
Validation through numerical simulations.
Application to ex vivo mouse brain and in vivo mouse whole-body imaging.

Main Results:

The multiview Hilbert transformation successfully recovered unipolar initial pressure.
Bipolar artifacts in PACT images were effectively resolved.
Demonstrated improved image quality in both simulated and real biological samples.

Conclusions:

The proposed multiview Hilbert transformation is an effective method for unipolar image recovery in full-ring PACT.
This technique enhances the diagnostic potential of PACT for small-animal studies.
It offers a valuable tool for clearer interpretation of optical absorption in biological tissues.