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Related Experiment Videos

Ocular side effects with 5-fluorouracil.

N Christophidis, F J Vajda, I Lucas

    Australian and New Zealand Journal of Medicine
    |April 1, 1979
    PubMed
    Summary
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    5-fluorouracil was detected in the tears of patients with excessive lacrimation but not in those without eye symptoms. This suggests the drug may cause lacrimal irritation and tear duct issues in some patients.

    Area of Science:

    • Oncology
    • Pharmacology
    • Ophthalmology

    Background:

    • 5-fluorouracil (5-FU) is a widely used chemotherapy agent for various cancers.
    • Ocular side effects, including lacrimal irritation, have been reported with 5-FU treatment.

    Purpose of the Study:

    • To investigate the presence and concentration of 5-fluorouracil in human tears.
    • To determine if 5-FU in tears correlates with ocular symptoms and patient characteristics.

    Main Methods:

    • Eight patients with carcinoma of the colon receiving 5-FU were studied.
    • Tear and plasma samples were collected and analyzed for 5-FU concentration using gas liquid chromatography.

    Main Results:

    • 5-fluorouracil was detected in the tears of patients experiencing excessive lacrimation (watery eyes).

    Related Experiment Videos

  • Peak tear concentrations ranged from 16-23.8 µg/ml, occurring 15 minutes post-IV administration.
  • 5-FU was undetectable in tears of patients without ocular symptoms, despite similar plasma concentrations (15-25 µg/ml).
  • Pharmacokinetic parameters (volume of distribution, plasma clearance) were comparable between groups.

    • Conclusions:

    • Approximately 30% of patients on 5-FU may experience lacrimal apparatus irritation.
    • The presence of 5-FU in tears might be responsible for reported ocular irritation and dacryostenosis.
    • Monitoring for ocular side effects is important in patients receiving 5-FU.