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Related Concept Videos

Immunocytochemistry and Immunohistochemistry01:22

Immunocytochemistry and Immunohistochemistry

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Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...
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Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
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Immunohistochemistry in Gynecologic Pathology: An Example-Based Practical Update.

Natalia Buza, Pei Hui1

  • 1From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Archives of Pathology & Laboratory Medicine
|July 27, 2017
PubMed
Summary

Immunohistochemistry aids gynecologic pathology diagnostics by refining criteria for lesions. New markers also offer prognostic insights and genetic screening for gynecologic cancers.

Area of Science:

  • Gynecologic Pathology
  • Immunohistochemistry
  • Diagnostic Pathology

Background:

  • Immunohistochemical stains are integral to gynecologic lesion diagnosis.

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  • Expanding marker availability refines disease criteria but presents challenges.
  • Understanding limitations is crucial for accurate interpretation.