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[Low back pain and Modic changes].

E L Sokov1, L E Kornilova1, A I Nesterov1

  • 1Peoples' Friendship University of Russia, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 27, 2017
PubMed
Summary
This summary is machine-generated.

Modic changes (MCh) involve vertebral bone marrow and endplate alterations, often causing persistent back pain. This review explores their pathogenesis, classification, and treatment, including novel osteogenic blockade methods.

Keywords:
aseptic spondylodiscitisbone marrow edemaintraosseous blockadelow back pain

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Area of Science:

  • Orthopedics
  • Radiology
  • Pathology

Background:

  • Modic changes (MCh) are MRI-detected vertebral alterations (edema, fatty degeneration, osteosclerosis).
  • MCh are frequently associated with persistent, varying-intensity back pain syndromes.
  • Clinical interpretation, MRI evaluation, and treatment of MCh present significant challenges.

Purpose of the Study:

  • To present a comprehensive overview of Modic changes.
  • To synthesize current national and international understanding of MCh pathogenesis, classification, and clinical implications.
  • To introduce the author's perspective on the osteogenic mechanism and treatment of MCh.

Main Methods:

  • Literature review of national and foreign sources.
  • Analysis of clinical data and MRI findings related to Modic changes.
  • Discussion of the proposed osteogenic mechanism and intraosseous blockade treatment.

Main Results:

  • Modic changes encompass a spectrum of bone marrow and endplate pathologies.
  • Persistent back pain is a dominant clinical manifestation of MCh.
  • Intraosseous blockades are proposed as a treatment targeting the osteogenic mechanism of MCh.

Conclusions:

  • Modic changes represent a complex spinal pathology impacting diagnosis and treatment.
  • A deeper understanding of MCh pathogenesis is crucial for effective management.
  • The proposed osteogenic mechanism and intraosseous blockade offer a novel therapeutic avenue for MCh-related pain.