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[Low back pain and Modic changes]

E L Sokov1, L E Kornilova1, A I Nesterov1

  • 1Peoples' Friendship University of Russia, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 27, 2017
PubMed

Insights

Modic changes (MCh) involve vertebral bone marrow and endplate alterations, often causing persistent back pain. This review explores their pathogenesis, classification, and treatment, including novel osteogenic blockade methods.

Area of Science:

  • Orthopedics
  • Radiology
  • Pathology

Background:

  • Modic changes (MCh) are MRI-detected vertebral alterations (edema, fatty degeneration, osteosclerosis).
  • MCh are frequently associated with persistent, varying-intensity back pain syndromes.
  • Clinical interpretation, MRI evaluation, and treatment of MCh present significant challenges.

Purpose of the Study:

  • To present a comprehensive overview of Modic changes.
  • To synthesize current national and international understanding of MCh pathogenesis, classification, and clinical implications.
  • To introduce the author's perspective on the osteogenic mechanism and treatment of MCh.

Main Methods:

  • Literature review of national and foreign sources.
  • Analysis of clinical data and MRI findings related to Modic changes.
  • Discussion of the proposed osteogenic mechanism and intraosseous blockade treatment.

Main Results:

  • Modic changes encompass a spectrum of bone marrow and endplate pathologies.
  • Persistent back pain is a dominant clinical manifestation of MCh.
  • Intraosseous blockades are proposed as a treatment targeting the osteogenic mechanism of MCh.

Conclusions:

  • Modic changes represent a complex spinal pathology impacting diagnosis and treatment.
  • A deeper understanding of MCh pathogenesis is crucial for effective management.
  • The proposed osteogenic mechanism and intraosseous blockade offer a novel therapeutic avenue for MCh-related pain.
Keywords:
aseptic spondylodiscitisbone marrow edemaintraosseous blockadelow back pain

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