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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
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[Membranous nephropathy in a Russian population].

V A Dobronravov1, D A Mayer1, O V Berezhnaya1

  • 1I.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Terapevticheskii Arkhiv
|July 27, 2017
PubMed
Summary

Primary membranous nephropathy (PMN) is common in Russia, often requiring treatment due to low spontaneous remission rates. Early diagnosis and tailored therapies, potentially including cyclophosphamide or cyclosporine, improve outcomes for PMN patients.

Keywords:
anti-PLA2R antibodiescomplete remissioncyclophosphamidecyclosporineglucocorticosteroidspartial remissionprimary membranous nephropathyspontaneous remission

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Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Membranous nephropathy (MN) is a significant cause of glomerulopathy.
  • Primary membranous nephropathy (PMN) constitutes a substantial portion of MN cases.
  • Understanding PMN's clinical and morphological features is crucial for effective management.

Purpose of the Study:

  • To analyze the clinical and morphological characteristics of membranous nephropathy (MN).
  • To evaluate the therapeutic efficacy in patients with primary membranous nephropathy (PMN).
  • To identify factors influencing treatment outcomes in PMN.

Main Methods:

  • Retrospective analysis of 201 MN cases diagnosed between 2009 and 2016.
  • Assessment of IgG-autoantibodies to phospholipase A2 receptor (anti-PLA2R Ab) titers.
  • Evaluation of treatment outcomes including proteinuria, nephrotic syndrome (NS), and remission rates (CR/PR).

Main Results:

  • PMN accounted for 10.4% of glomerulopathies; 24.9% of MN cases had secondary causes.
  • Elevated anti-PLA2R Ab levels were detected in 51.6% of patients.
  • Complete or partial remission (CR/PR) was achieved in 68% of treated patients, with improved rates using cyclophosphamide/cyclosporine.

Conclusions:

  • PMN is a prevalent glomerulopathy in Russia with low spontaneous remission rates.
  • Detection of anti-PLA2R antibodies is a key feature in Russian PMN cases.
  • Timely diagnosis and individualized treatment are essential for renal protection in PMN.