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The correlation between cognitive impairment and ambulatory blood pressure in patients with cerebral small vessel

X-F Li1, L-M Cui, D-K Sun

  • 1Neurosurgery Ward 2, Linyi City Yishui Central Hospital Shandong Province, China. lmlfdeg801@163.com.

European Review for Medical and Pharmacological Sciences
|July 27, 2017
PubMed

Insights

Cognitive impairment in cerebral small vessel disease (CSVD) patients is linked to abnormal ambulatory blood pressure. Managing blood pressure may reduce cognitive decline in these individuals.

Area of Science:

  • Neurology
  • Cardiology
  • Gerontology

Background:

  • Cerebral small vessel disease (CSVD) is a common cause of cognitive impairment.
  • Ambulatory blood pressure monitoring (ABPM) provides continuous hemodynamic data.
  • The relationship between ABPM and cognitive function in CSVD requires further investigation.

Purpose of the Study:

  • To investigate the correlation between cognitive impairment and ambulatory blood pressure (ABP) in patients with CSVD.
  • To compare ABP parameters between CSVD patients with and without cognitive impairment.

Main Methods:

  • 108 CSVD patients were assessed using the Montreal Cognitive Assessment (MoCA).
  • Patients were categorized into cognitive impairment (n=39) and normal (n=69) groups.
  • 24-hour ABPM was performed, and correlations with MoCA scores were analyzed.

Main Results:

  • Significant differences in ambulatory systolic blood pressure, pulse pressure, and nocturnal blood pressure reduction were observed between groups (p < 0.05).
  • Diastolic blood pressure showed no significant differences (p > 0.05).
  • Ambulatory systolic blood pressure, pulse pressure, and nocturnal blood pressure reduction were negatively correlated with MoCA scores (p < 0.05).

Conclusions:

  • Cognitive impairment in CSVD patients is closely associated with ABP parameters.
  • Elevated systolic blood pressure, pulse pressure, and impaired nocturnal blood pressure dipping are potential risk factors for cognitive decline in CSVD.
  • Optimizing blood pressure management could mitigate cognitive impairment incidence in CSVD.
Abstract

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