Expression of miR-210 in senile COPD complicating primary lung cancer

To analyze the expression and clinical significance of miR-210 in patients with senile chronic obstructive pulmonary disease (COPD) complicating primary lung cancer. 30 cases of COPD PATIENTS AND METHODS: 30 cases of primary lung cancer and 30 cases of COPD complicating lung cancer were selected. MiR-210 can function as the cancer suppressor gene in progress from COPD to primary lung cancer and may be used as an important auxiliary diagnosis index. Analysis of correlations between MiR-210 expression with clinical features such as age, sex, disease type, COPD disease classification, pathological pattern of neoplasia and TNM staging.

The expression of miR-210 of COPD Group was significantly higher than the Lung Cancer Group. The level of COPD Complicating Lung Cancer was the lowest (p < 0.05). There was no remarkable difference among sex, age, smoking status, hypertension, diabetes mellitus and pathological type in each group (p > 0.05). Expression of miR-210 was lower with the aggravation of COPD and an increase of TNM staging (p < 0.05).

MiR-210 expression level in the diagnosis of COPD complicating lung cancer had the sensitivity of 76.8%, specificity of 72.3%, accuracy of 0.73, 95% CI of 0.63-0.85 and critical value of 0.1825.