Ionic Liquids as Tool to Improve Enzymatic Organic Synthesis
1Department of Chemistry and Biotechnology, Graduate School of Engineering and ‡Center for Research on Green Sustainable Chemistry, Tottori University , 4-101 Koyama-minami, Tottori 680-8552, Japan.
Chemical Reviews
|July 27, 2017
Summary
Ionic liquids (ILs) are versatile media for biocatalysis, enabling diverse enzymatic reactions for organic synthesis. Research highlights ILs
Area of Science:
- Biocatalysis and Green Chemistry
- Enzymatic Organic Synthesis
- Ionic Liquid Applications
Background:
- Ionic liquids (ILs) have emerged as significant reaction media for biotransformations since 2000.
- Numerous applications of ILs in biocatalytic reactions have been reported, expanding their utility in organic synthesis.
Purpose of the Study:
- To review the diverse applications of ionic liquids (ILs) in biocatalysis for organic synthesis.
- To explore enzymatic reactions mediated by ILs and the activation of enzymes using ILs.
Main Methods:
- Literature review of biocatalytic reactions employing ILs as reaction media.
- Categorization of enzymatic reactions based on enzyme class and IL application.
- Discussion of enzyme activation strategies using ILs.
Main Results:
- ILs facilitate a wide array of biocatalytic reactions including lipase, oxidase, laccase, and protease-catalyzed processes.
- Specific applications include biodiesel production, sugar ester synthesis, and asymmetric ketone reduction.
- Enzymes can be activated by ILs, such as lipases coated with PEG-substituted ILs.
Conclusions:
- Ionic liquids offer a promising and versatile medium for a broad spectrum of enzymatic reactions in organic synthesis.
- The activation of enzymes by ILs presents novel opportunities for enhancing biocatalytic efficiency.
- Future research should continue to explore the potential of ILs in biocatalysis and green chemistry.
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