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Solid lipid nanoparticles improve octyl gallate antimetastatic activity and ameliorate its renal and hepatic toxic

Clarissa A S Cordova1, Claudriana Locatelli, Evelyn Winter

  • 1aDepartment of Pharmaceutical Sciences bDepartment of Biochemistry cDepartment of Chemistry, Federal University of Santa Catarina dNanovetores Technology S.A., Florianópolis eUniversity of Western Santa Catarina, Videira, SC fFederal University of Tocantins, Araguaína, TO, Brazil.

Anti-Cancer Drugs
|July 27, 2017
PubMed

Insights

Octyl gallate (G8) and its nanoparticle formulation (G8-NVM) effectively inhibited lung metastasis in mice. G8-NVM significantly reduced cancer spread and toxicity compared to free G8, offering a promising anticancer strategy.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Metastasis is a primary cause of cancer mortality, necessitating novel treatments with improved efficacy and reduced toxicity.
  • Gallic acid derivatives, such as octyl gallate (G8), possess demonstrated antitumoral properties.
  • Developing effective anticancer therapies with lower side effects is crucial.

Purpose of the Study:

  • To evaluate the antimetastatic potential of free octyl gallate (G8) and solid lipid nanoparticle-loaded G8 (G8-NVM).
  • To assess the toxicological profile of G8 and G8-NVM in a murine lung metastasis model.

Main Methods:

  • Melanoma cells were inoculated into mice to establish a lung metastasis model.
  • Mice were treated with free G8 or G8-NVM.
  • Metastasis inhibition and toxicological parameters were evaluated.

Main Results:

  • Both G8 and G8-NVM treatments significantly inhibited lung metastasis.
  • G8 treatment led to increased toxicological parameters in mice.
  • G8-NVM treatment largely circumvented the toxic effects observed with free G8.

Conclusions:

  • Octyl gallate exhibits antimetastatic activity, which can be enhanced and made safer through nanotechnology.
  • Solid lipid nanoparticle formulation of G8 (G8-NVM) offers a promising approach to reduce chemotherapy-related toxicity while maintaining anticancer efficacy.
  • Further research into plant-derived compounds and nanotechnology is warranted for improved cancer treatment strategies.

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