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The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats

Aleksandra Vranic1, Stefan Simovic2, Petar Ristic3

  • 1a Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Canadian Journal of Physiology and Pharmacology
|July 27, 2017
PubMed

Insights

Mineralocorticoid receptor antagonists like spironolactone may benefit heart function in diabetes. This study found spironolactone

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Cardiovascular diseases are the leading cause of global mortality.
  • Diabetes mellitus contributes significantly to cardiovascular morbidity.
  • Mineralocorticoid receptor antagonists show promise in improving cardiac function in diabetic patients.

Purpose of the Study:

  • To evaluate the acute effects of spironolactone on myocardial function in a rat model of diabetes mellitus.
  • To investigate dose-dependent responses of spironolactone on cardiac parameters in healthy and diabetic rat hearts.
  • To emphasize cardiodynamic changes in diabetic rat hearts following spironolactone administration.

Main Methods:

  • Utilized 40 adult male Wistar albino rats, randomly assigned to four groups.
  • Groups included healthy and streptozotocin-induced diabetic rats, treated with either 0.1 μmol/L or 3 μmol/L spironolactone.
  • Assessed myocardial function using isolated, working heart preparations, focusing on cardiodynamic parameters.

Main Results:

  • Observed different, dose-dependent acute responses to spironolactone in healthy and diabetic rat hearts.
  • In healthy rats, higher spironolactone doses improved systolic function.
  • In diabetic rats, both low and high spironolactone doses produced similar effects on cardiac function.

Conclusions:

  • Spironolactone exhibits differential effects on myocardial function in healthy versus diabetic hearts.
  • The dose-dependent impact of spironolactone on cardiac function is evident in healthy hearts but less pronounced in diabetic hearts.
  • Further research is warranted to elucidate the therapeutic potential of spironolactone in diabetic cardiovascular complications.

Keywords:
cardiodynamicscardiodynamiecœur isoléisolated heartoxidative parameterparamètre de l’oxydationratspironolactonestreptozotocinstreptozotocine

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