Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Modeling HIV infection, treatment, rebound, and intervention in human immune organoids.

bioRxiv : the preprint server for biology·2026

Same author

Leveraging HIV-Specific CAR T Cells and Rapamycin Treatment in "Kick-and-Kill" HIV Cure Approaches.

bioRxiv : the preprint server for biology·2026

Same author

NK Cells Engineered with a Chimeric Antigen Receptor Delay HIV Rebound and Reshape HIV Reservoir Composition.

bioRxiv : the preprint server for biology·2026

Same author

Author Correction: Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns.

Nature communications·2025

Same author

Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns.

Nature communications·2025

Same author

Rapamycin enhances CAR-T control of HIV replication and reservoir elimination in vivo.

The Journal of clinical investigation·2025

Search research articles

Related Experiment Video

Updated: Feb 25, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Humanized Mouse Models for Human Immunodeficiency Virus Infection.

Matthew D Marsden¹, Jerome A Zack^1,2

¹Department of Medicine, Division of Hematology and Oncology, University of California, Los Angeles, California 90095;

Annual Review of Virology

|July 27, 2017

Summary

Human immunodeficiency virus (HIV) research utilizes humanized mice to study infection and immune responses. These advanced models are crucial for developing new HIV prevention and cure strategies.

Keywords:

AIDS BLT HIV humanized mice model

More Related Videos

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Humanized NOD/SCID/IL2rγ^null (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Feb 25, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection

Published on: January 31, 2020

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Humanized NOD/SCID/IL2rγ^null (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Area of Science:

Immunology
Virology
Infectious Diseases

Background:

Human immunodeficiency virus (HIV) causes significant global morbidity and mortality.
Current antiretroviral therapy manages HIV but does not provide a cure.
Effective HIV vaccines are still unavailable, necessitating further research.

Purpose of the Study:

To review major humanized mouse models used in HIV research.
To highlight recent advances in HIV therapeutics and pathogenesis studies using these models.
To underscore the importance of humanized mice in understanding HIV-human immune system interactions.

Main Methods:

Description of established humanized mouse models.
Transplantation of human cells or immune systems into immunodeficient mice.
Utilizing these models to investigate HIV pathogenesis and persistence.

Main Results:

Humanized mice serve as critical tools for studying HIV.
These models facilitate research into the interaction between HIV and the human immune system.
Advances in HIV therapeutics and research have been achieved using humanized mice.

Conclusions:

Humanized mouse models are indispensable for advancing HIV research.
Continued development and application of these models are vital for combating the HIV epidemic.
Humanized mice offer a promising platform for developing novel HIV cure and prevention strategies.