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Related Experiment Videos

Tardive dyskinesia in the elderly.

F M Ramsay, P H Millard

    Age and Ageing
    |May 1, 1986
    PubMed
    Summary

    In elderly individuals, dyskinetic movements affect 11.5%, with orofacial movements being most common. Neuroleptic drug use, particularly chlorpromazine and flupenthixol, significantly increases the risk of developing these abnormal movements.

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    Area of Science:

    • Gerontology
    • Neuroscience
    • Pharmacology

    Background:

    • Dyskinetic movements, characterized by involuntary, abnormal movements, are a potential concern in the elderly population.
    • The prevalence and risk factors for dyskinetic movements in older adults require further investigation.

    Purpose of the Study:

    • To assess the prevalence of dyskinetic movements in an elderly cohort.
    • To identify potential associations between dyskinetic movements and factors such as neuroleptic drug exposure, age, and dementia.

    Main Methods:

    • A cross-sectional study involving 426 elderly subjects.
    • Assessment for the presence and type of dyskinetic movements.
    • Analysis of medical history, including neuroleptic drug use, age, and dementia status.

    Main Results:

    • Dyskinetic movements were observed in 11.5% of the subjects.
    • Orofacial movements, particularly chewing, were the most frequent type (92%).
    • A significant association was found between dyskinetic movements and the use of chlorpromazine and flupenthixol. Subjects who had received neuroleptic drugs had a higher prevalence (20.8%) compared to neuroleptic-naïve subjects (8%).

    Conclusions:

    • Dyskinetic movements are relatively common in the elderly, with orofacial movements being predominant.
    • Neuroleptic drug exposure, specifically chlorpromazine and flupenthixol, is a significant risk factor for developing dyskinetic movements in this population.
    • Advancing age and dementia were not associated with an increased risk of dyskinetic movements.

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