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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.0K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Related Experiment Video

Updated: Feb 25, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
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White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

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497

Leptin and autoimmune disease.

Yoshimasa Fujita1

  • 1Department of Hematology and Clinical Immunology, Kanazawa Medical University.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|July 28, 2017
PubMed
Summary

Leptin, a hormone from fat cells, impacts appetite and energy. It also affects immune cells, potentially worsening autoimmune diseases, suggesting leptin signal inhibition as a therapeutic strategy.

Area of Science:

  • Immunology
  • Endocrinology
  • Metabolism

Background:

  • Leptin, secreted by adipocytes, primarily regulates appetite and energy expenditure via hypothalamic action.
  • Leptin receptors are present on hematopoietic cells, indicating a role in immune system function.
  • Emerging evidence highlights leptin's significance in the pathogenesis of autoimmune diseases.

Purpose of the Study:

  • To review the current understanding of leptin's role in the immune system.
  • To discuss the implications of leptin signaling in autoimmune disease development.
  • To explore leptin signal inhibition as a potential therapeutic avenue for autoimmune conditions.

Main Methods:

  • Literature review of current scientific reports and studies.
  • Analysis of existing data on leptin's interaction with immune cells.
Keywords:
autoimmune diseaseleptinrheumatoid arthritissystemic lupus erhthematosus

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  • Synthesis of findings regarding leptin's influence on autoimmune disease progression.

    • Main Results:

    • Leptin's dual role in metabolism and immunity is increasingly recognized.
    • Leptin has been identified as an exacerbating factor in several autoimmune diseases.
    • The leptin signaling pathway presents a potential target for therapeutic intervention.

    Conclusions:

    • Leptin significantly influences immune system function.
    • Targeting leptin signaling may offer a novel therapeutic strategy for managing autoimmune diseases.
    • Further research is warranted to fully elucidate leptin's immunomodulatory effects and therapeutic potential.