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Updated: Feb 25, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Complement in Non-Antibody-Mediated Kidney Diseases.

Andrea Angeletti1,2, Joselyn Reyes-Bahamonde1, Paolo Cravedi1

  • 1Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Frontiers in Medicine
|July 28, 2017
PubMed
Summary

The complement system, crucial for immunity, drives kidney disease progression. New anticomplement therapies offer promising treatments for these complement-related kidney diseases.

Keywords:
complement systemfibrosisfocal segmental glomerulosclerosisglomerular diseasethrombotic microangiopathy

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Area of Science:

  • Immunology
  • Nephrology
  • Pathophysiology

Background:

  • The complement system is vital for innate immunity against pathogens.
  • Complement activation contributes to autoantibody-related glomerulopathies and non-antibody-mediated kidney diseases.
  • Unregulated complement activation, particularly the alternative pathway, drives kidney disease progression and fibrosis.

Purpose of the Study:

  • To review complement system activation and regulation.
  • To examine the role of complement in non-antibody-mediated glomerular diseases.
  • To discuss advances in complement-targeting therapies for kidney diseases.

Main Methods:

  • Literature review of complement system mechanisms.
  • Analysis of complement's role in various kidney diseases.
  • Survey of current and emerging anticomplement agents.

Main Results:

  • The alternative pathway is a key driver in many complement-mediated kidney diseases.
  • Several anticomplement agents are approved or in development.
  • Therapeutic targeting of the complement system is a viable strategy.

Conclusions:

  • Complement system dysregulation significantly impacts kidney disease pathogenesis.
  • Anticomplement therapies hold substantial promise for treating complement-related kidney diseases.
  • Further research into complement pathways and targeted therapies is warranted.