Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis
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Updated: Feb 25, 2026

The MultiBac Protein Complex Production Platform at the EMBL
Published on: July 11, 2013
Alexander K W Elsholz1, Marlene S Birk1, Emmanuelle Charpentier1,2,3
1Department of Regulation in Infection Biology, Max Planck Institute for Infection BiologyBerlin, Germany.
Abstract:
Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.
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