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Estimation of Contact Regions Between Hands and Objects During Human Multi-Digit Grasping
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The extended object-grasping network.

Marzio Gerbella1,2, Stefano Rozzi3, Giacomo Rizzolatti4,5

  • 1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies (CBN), Lecce, Italy.

Experimental Brain Research
|July 28, 2017
PubMed
Summary
This summary is machine-generated.

Higher brain areas in the prefrontal cortex control grasping by influencing premotor areas. These areas, specifically F5a and F6, are crucial for object analysis and deciding when and how to grasp.

Keywords:
Contextual controlGoal codingPrefrontal cortexPremotor cortexSIISensorimotor transformation for object grasping

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Area of Science:

  • Neuroscience
  • Primate motor control
  • Sensorimotor transformations

Background:

  • Grasping is a vital skilled motor act for primates, relying on sensorimotor transformations.
  • The core grasping circuit involves inferior parietal areas (AIP, PFG) and ventral premotor area F5.
  • Higher-order information, like object meaning and action goals, also influences grip selection.

Purpose of the Study:

  • To review recent findings on the role of ventrolateral prefrontal cortex in higher-order grasping control.
  • To elucidate the pathways through which prefrontal cortex influences grasping.
  • To describe specific functions of prefrontal gateways F5a and F6 in grasping.

Main Methods:

  • Review of functional studies and recent findings.
  • Analysis of neural pathways connecting prefrontal cortex to premotor areas.
  • Examination of neuronal encoding in specific brain regions.

Main Results:

  • Ventrolateral prefrontal cortex sectors control higher-order grasping aspects via gateways F5a and F6.
  • Sub-area F5a is involved in 3D object stereoscopic analysis and cue-dependent grasping.
  • Area F6 plays a key role in the timing of motor program execution and potentially grip type selection.

Conclusions:

  • Prefrontal cortex exerts significant control over grasping beyond basic sensorimotor transformations.
  • Areas F5a and F6 are critical relay stations and functional hubs in the grasping network.
  • Understanding these circuits may inform clinical syndromes affecting grasping actions.