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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Whole brain analyses of age-related microstructural changes quantified using different diffusional magnetic resonance

Miho Ota¹, Noriko Sato², Norihide Maikusa³

¹Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan. ota@ncnp.go.jp.

Japanese Journal of Radiology

|July 28, 2017

Summary

New brain imaging techniques, diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI), show similar tendencies in reflecting microstructural changes. DKI and NODDI are sensitive to age-related brain alterations.

Keywords:

Biological parametric mapping Diffusional kurtosis imaging Neurite density index Neurite orientation dispersion and density imaging Orientation dispersion index

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Area of Science:

Neuroimaging
Biophysics
Medical Physics

Background:

Diffusion magnetic resonance imaging (dMRI) techniques like DKI and NODDI aim to elucidate microstructural brain changes.
Limited data exists on the comparative performance of these advanced dMRI metrics.

Purpose of the Study:

To investigate the similarities and differences between DKI and NODDI metrics.
To compare the effects of aging on these microstructural imaging metrics.

Main Methods:

Twenty-three healthy subjects underwent dMRI scans.
Image-by-image paired t-tests were used to assess metric relationships.
Aging effects on each metric were evaluated.

Main Results:

Fractional anisotropy (FA), mean kurtosis (MK), and neurite density index (NDI) showed positive correlations.
Mean diffusivity (MD) and orientation dispersion index (ODI) negatively correlated with FA.
MK, ODI, and NDI correlated significantly with age, unlike FA and MD.

Conclusions:

DKI and NODDI metrics exhibit similar trends in reflecting microstructural organization.
NODDI and DKI demonstrate higher sensitivity to age-related changes in brain tissue.
These advanced dMRI techniques show promise for studying normal and degenerated brain changes.