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Related Concept Videos

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Related Experiment Video

Updated: Feb 25, 2026

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
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Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

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Concise Review: Stem Cells for Corneal Wound Healing.

Mehrnoosh Saghizadeh1,2, Andrei A Kramerov1, Clive N Svendsen1,2

  • 1Cedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, California, USA.

Stem Cells (Dayton, Ohio)
|July 28, 2017
PubMed
Summary

Stem cells are crucial for corneal wound healing following injury or surgery. This review explores their role and potential therapeutic applications, including using pluripotent stem cells for transplantation.

Keywords:
Cell transplantationCorneal endotheliumCorneal epitheliumGene therapyKeratocytePluripotent stem cellStem cellWound healing

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Corneal wound healing is a complex biological process following injury or refractive surgery.
  • Dysfunctional healing (epithelial or stromal) can lead to significant clinical complications.
  • The roles of epithelial, stromal, and endothelial progenitor cells in corneal repair are not fully understood.

Purpose of the Study:

  • To review the current evidence on stem cell involvement in corneal wound healing.
  • To discuss the therapeutic potential of corneal and non-corneal stem cells in treating corneal conditions.
  • To present methods for generating corneal stem cells from alternative sources for transplantation.

Main Methods:

  • Literature review of studies on stem cells and corneal wound healing.
  • Analysis of data on stem cell transplantation for corneal repair.
  • Discussion of stem cell differentiation and generation techniques.

Main Results:

  • Epithelial stem cells are key players in corneal repair.
  • Stromal and endothelial progenitor contributions require further investigation.
  • Corneal and non-corneal stem cells show promise for therapeutic applications.
  • Pluripotent stem cells offer a potential source for generating corneal stem cells.

Conclusions:

  • Stem cells are vital for effective corneal wound healing.
  • Harnessing stem cell therapies can address complications from corneal injuries and diseases.
  • Further research into stem cell mechanisms and applications is warranted for clinical translation.