Lane's type pseudosarcoma of glans penis

Area of Science:

• Uropathology
• Oncology
• Dermatopathology

Background:

• Pseudosarcomatous lesions, initially described in the upper aerodigestive tract, are rare in other locations.
• Squamous cell carcinoma can present with or be associated with these benign-appearing lesions.

Observation:

• A case of polypoid pseudosarcomatous lesion of the glans penis is presented.
• The lesion was associated with in situ or minimally invasive squamous carcinoma.

Findings:

• Immunohistochemistry is essential for accurate diagnosis.
• Atypical cells were identified as components of granulation tissue, including fibroblasts, myofibroblasts, and endothelial cells.

Implications:

• This case highlights the importance of considering rare penile lesions.
• Accurate immunohistochemical analysis is critical to differentiate benign reactive changes from true malignancy.
• Understanding the cellular origin of these lesions aids in appropriate patient management.