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Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

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DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
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Hemodialysis I: Introduction01:25

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Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
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Dialysis01:15

Dialysis

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Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
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Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

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Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
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Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

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Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
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Related Experiment Video

Updated: Feb 25, 2026

Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs
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Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of Biomacromolecular Drugs

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Haemolysis in haemodialysis.

Dhakshayini Tharmaraj1, Peter G Kerr1

  • 1Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.

Nephrology (Carlton, Vic.)
|July 28, 2017
PubMed
Summary

Haemolysis during haemodialysis, though rare, carries high mortality risks. Prompt recognition, root cause analysis, and correction of factors causing haemolysis are vital for patient safety.

Area of Science:

  • Nephrology
  • Hematology
  • Clinical Medicine

Background:

  • Haemolysis in haemodialysis (HD), while infrequent, is linked to severe patient outcomes.
  • Identifying and addressing the causes of haemolysis is critical due to its potential for mortality and morbidity.

Purpose of the Study:

  • To highlight the importance of recognizing and managing haemolysis in haemodialysis patients.
  • To discuss the multifactorial causes and consequences of haemolysis in HD.

Main Methods:

  • Review of clinical manifestations and potential complications of haemolysis.
  • Analysis of contributing factors including dialysate, extracorporeal circuit, and patient-related elements.
  • Discussion of advancements reducing haemolysis incidence.
Keywords:
anemiachloraminehemodialysishemolysisuremia

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Main Results:

  • Haemolysis presents with non-specific symptoms like hypertension, nausea, and pain.
  • Severe consequences include cardiac arrhythmias, profound anemia, respiratory distress, and pancreatitis.
  • Chronic haemolysis impairs endothelial function, increasing cardiovascular risk.

Conclusions:

  • Despite reduced incidence due to improved standards and technology, clinical vigilance for haemolysis in HD is essential.
  • Prompt recognition, treatment, and root cause analysis remain paramount for managing haemolysis events.