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Correlation between CAT polymorphism and susceptibility to DMAc-induced abnormal liver function: a case-control study
Xianping Song1,2, Wei Gong2, Huanxi Shen3
1a Department of Occupational and Environmental Health, School of Public Health , Nanjing Medical University , Nanjing , Jiangsu , China.
Summary
The CAT rs769214 polymorphism may protect against N,N-dimethylacetamide (DMAc)-induced liver damage in Chinese workers. This protective effect was more pronounced in individuals with shorter DMAc exposure and healthier lifestyles.
Area of Science:
- Toxicology
- Genetics
- Occupational Health
Background:
- N,N-dimethylacetamide (DMAc) exposure can cause abnormal liver function.
- DMAc metabolism generates reactive oxygen species (ROS), contributing to liver toxicity.
- ROS elimination and DNA repair mechanisms are crucial in mitigating DMAc toxicity.
Purpose of the Study:
- To examine the association between specific gene polymorphisms (CAT, hOGG1, XRCC1) and susceptibility to DMAc-induced abnormal liver function.
- Focus on a Chinese population of workers exposed to DMAc.
Main Methods:
- Case-control study involving 108 workers with DMAc-induced abnormal liver function and 108 healthy controls.
- Genotyping of CAT (rs564250, rs769214, rs7943316), hOGG1 (rs2072668, rs159153), and XRCC1 (rs25487, rs1799782) polymorphisms.
Main Results:
- The CAT rs769214 GA/GG genotypes were associated with a reduced risk of abnormal liver function.
- This protective association was stronger in subgroups with less than 10 years of DMAc exposure, lower exposure levels (<5 mg/m³), and among non-smokers and non-drinkers.
Conclusions:
- The CAT rs769214 (-844 G>A) polymorphism may play a protective role against DMAc-induced abnormal liver function in the Chinese population.
- Genetic variations in antioxidant enzyme genes could influence individual susceptibility to occupational chemical exposure.
