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Updated: Feb 25, 2026
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A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
Published on: October 19, 2018
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Esophageal endoscopic submucosal dissection using sodium hyaluronate is safe and effective
Chihiro Iwashita1, Hirotsugu Sakamoto1, Yoshimasa Miura1
1a Division of Gastroenterology, Department of Medicine , Jichi Medical University , Shimotsuke , Japan.
Summary
Sodium hyaluronate is effective for endoscopic submucosal dissection (ESD) of superficial esophageal squamous cell neoplasms (ESCN). This method achieves a high R0 resection rate with a low incidence of adverse events, demonstrating its safety and utility.
Area of Science:
- Gastroenterology
- Endoscopy
- Oncology
Background:
- Sodium hyaluronate submucosal injection is established for gastric and colorectal endoscopic submucosal dissection (ESD).
- Limited research exists on its application for esophageal lesions.
Purpose of the Study:
- To evaluate the utility and safety of sodium hyaluronate for endoscopic submucosal dissection (ESD) of superficial esophageal squamous cell neoplasms (ESCN).
Main Methods:
- Retrospective review of 111 ESCN cases treated with ESD between September 2007 and April 2013.
- Analysis of 107 ESD procedures, excluding four cases of double cancers.
Main Results:
- High en bloc resection rate (99%) and R0 resection rate (93%).
- Low rates of delayed bleeding (2%) and intra-procedural perforation (4%), with no operative repair needed.
- Post-ESD stenosis occurred in 5% of cases, managed with dilation.
Conclusions:
- Sodium hyaluronate is a safe and effective submucosal agent for ESD in ESCN.
- It facilitates high R0 resection rates with manageable adverse events.
