Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

7.8K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.8K
Computed Tomography01:10

Computed Tomography

9.1K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.1K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

668
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
668
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

452
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
452
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

529
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
529
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

3.0K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultra-dense lutetium oxide ceramic scintillators for positron emission tomography.

Physics in medicine and biology·2026
Same author

Simultaneous attenuation and scatter correction of PET data in the image: quantitative and clinical assessment of image-to-image deep learning models.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Assessing the feasibility of deep learning-based attenuation correction using photon emission data in<sup>18</sup>F-FDG images for dedicated head and neck PET scanners.

Biomedical physics & engineering express·2025
Same author

Effect of Span and MRD Configurations on Small Animal PET Image Quality and Quantitative Accuracy.

Journal of biomedical physics & engineering·2025
Same author

Automated pulmonary nodule classification from low-dose CT images using ERBNet: an ensemble learning approach.

Medical & biological engineering & computing·2025
Same author

Robust vs. Non-robust radiomic features: the quest for optimal machine learning models using phantom and clinical studies.

Cancer imaging : the official publication of the International Cancer Imaging Society·2025

Related Experiment Video

Updated: Feb 25, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

725

Compton scatter tomography in TOF-PET.

Hamidreza Hemmati1, Alireza Kamali-Asl1, Mohammadreza Ay2,3

  • 1Department of Medical Radiation Engineering, Shahid Beheshti University, Tehran, Iran.

Physics in Medicine and Biology
|July 28, 2017
PubMed
Summary

This study introduces a new method to reconstruct positron emission tomography (PET) images using scattered coincidence data. By leveraging time of flight (TOF) and energy information, this approach can improve image quality in future PET systems.

More Related Videos

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

9.0K
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K

Related Experiment Videos

Last Updated: Feb 25, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

725
A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

9.0K
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Physics

Background:

  • Scatter coincidences in Positron Emission Tomography (PET) traditionally blur images and are subtracted.
  • List mode data offers opportunities to utilize time of flight (TOF) and energy information from coincidences.
  • Conventional PET reconstruction methods do not fully exploit information contained within scattered photons.

Purpose of the Study:

  • To develop a novel method for reconstructing activity distribution in PET systems by utilizing scatter coincidence data.
  • To investigate the impact of TOF and energy resolution on the proposed scatter data reconstruction method.
  • To explore the potential of scatter data for enhancing image quality in next-generation PET scanners.

Main Methods:

  • Determining scattering angles from detected photon energies to calculate possible scattering locations.
  • Utilizing geometric equations to define scattering sites on arcs (2D) or prolate spheroids (3D).
  • Employing a novel technique to estimate source locations from scattering sites using TOF information.
  • Performing Monte Carlo simulations with uniform and non-uniform phantoms to evaluate the method.

Main Results:

  • The proposed method can reconstruct activity distribution using scattered PET data.
  • Energy uncertainties negatively impact image spatial resolution, while time resolution significantly affects image quality.
  • Scattered data reconstruction shows potential for complementary use or image quality improvement in advanced PET systems.

Conclusions:

  • Reconstructing PET images using scatter coincidences is feasible and can provide valuable information.
  • Time of flight (TOF) resolution is a critical factor for successful scatter data utilization in PET.
  • This approach offers a pathway to enhance the performance of future PET imaging systems.