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F wave index: A diagnostic tool for peripheral neuropathy
G R Sathya1, N Krishnamurthy1, Susheela Veliath1
1Department of Physiology, Pondicherry Institute of Medical Sciences, Puducherry, India.
The Indian Journal of Medical Research
|July 28, 2017
Summary
The F wave index, a new diagnostic tool, is significantly lower in individuals with peripheral neuropathy. This index aids in the early detection of peripheral nerve damage.
Area of Science:
- Neuroscience
- Clinical Electrophysiology
Background:
- Peripheral neuropathy diagnosis can be challenging due to overlapping nerve root involvement.
- Standard F-wave latency may appear normal even with nerve root compromise.
- A novel F-wave index incorporating multiple parameters is proposed for improved diagnostic accuracy.
Purpose of the Study:
- To construct and validate an F-wave index for the upper limb median nerve.
- To assess the F-wave index's utility in differentiating peripheral neuropathy patients from healthy controls.
Main Methods:
- A hospital-based study involving 40 male patients with peripheral neuropathy and 40 age-matched healthy males.
- F-wave recordings were performed using a digitalized nerve conduction/electromyography/EP machine.
- Median nerve stimulation was applied to the abductor pollicis brevis muscle under controlled environmental conditions.
Main Results:
- The median F-wave index was significantly lower in the peripheral neuropathy group (right arm: 35.85, left arm: 39.49) compared to the control group (right arm: 102.62, left arm: 77.43).
- Statistical analysis confirmed a significant difference (P=0.001) between the groups.
Conclusions:
- The F-wave index is significantly reduced in patients with peripheral neuropathy.
- This index demonstrates potential as a valuable tool for the early detection of peripheral neuropathy.
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