Nickel-Catalyzed Coupling of Azoles with Aromatic Nitriles
Mckenna G Hanson1, Noelle M Olson1, Zubaoyi Yi1
1Department of Chemistry, St. Olaf College , 1520 St. Olaf Avenue, Northfield, Minnesota 55057, United States.
Abstract:
This manuscript describes the Ni-catalyzed coupling of azoles with aromatic nitriles. The use of BPh3 promotes these arylations with electronically diverse azoles and benzonitriles. While the nickel catalyst is necessary for the arylations of phenyl oxazoles, arylation of benzoxazoles with some nitriles affords the arylated products even in the absence of the Ni catalyst albeit in lower yield than the catalyzed process. The Ni-catalyzed process exhibits higher rates and a broader scope than the uncatalyzed transformation.
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