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Lack of association between cystatin C and different coronary atherosclerotic manifestations

Trine R Larsen1, Oke Gerke2,3, Axel C P Diederichsen4

  • 1a Department of Clinical Biochemistry , Svendborg Hospital , Svendborg , Denmark.

Scandinavian Journal of Clinical and Laboratory Investigation
|July 28, 2017
PubMed

Insights

Cystatin C (CysC) levels did not correlate with coronary artery calcification in asymptomatic individuals. CysC was also not linked to type 1 myocardial infarction, but was higher in type 2 myocardial infarction and elevated troponin groups.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Chemistry

Background:

  • Cystatin C (CysC) is a known biomarker associated with cardiovascular disease (CVD), including coronary artery disease (CAD) and adverse clinical events.
  • Previous research suggests a link between CysC and CVD, but its association with specific manifestations like coronary artery calcification (CAC) and different types of myocardial infarction (MI) requires further investigation.

Purpose of the Study:

  • To investigate the association between serum Cystatin C (CysC) levels and coronary artery calcification (CAC) in asymptomatic individuals.
  • To examine CysC levels in different subgroups of patients with suspected or confirmed acute myocardial infarction (MI), including type 1 MI, type 2 MI, and elevated troponin without MI.

Main Methods:

  • Serum CysC levels were measured in 1039 asymptomatic individuals screened for CAC using non-contrast cardiac CT.
  • CysC levels were also analyzed in 769 hospitalized patients with suspected MI, categorized into type 1 MI, type 2 MI, and elevated troponin without MI groups.
  • Statistical analyses were performed to adjust for relevant risk factors.

Main Results:

  • Cystatin C (CysC) was not found to be associated with coronary artery calcification (CAC) in asymptomatic individuals after adjusting for risk factors.
  • No significant difference in CysC levels was observed between patients with type 1 MI and those with normal troponin levels.
  • Patients with type 2 MI and those with elevated troponin but without MI showed significantly higher CysC levels compared to type 1 MI patients, even after risk factor adjustment.

Conclusions:

  • Cystatin C (CysC) is not associated with coronary artery calcification (CAC) in middle-aged asymptomatic individuals from the general population.
  • CysC levels do not appear to be a reliable marker for type 1 myocardial infarction (MI).
  • Elevated CysC levels in type 2 MI and elevated troponin groups suggest a potential role in specific pathophysiological pathways distinct from type 1 MI or atherosclerosis.

Keywords:
Cystatin Catherosclerosiscoronary artery diseasemyocardial infarctionmyocardial ischaemiatroponins and cardiac biomarkersvascular calcification

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