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Heart rate variability in multibacillar leprosy: Linear and nonlinear analysis.

Marcio Clementino de Souza Santos1,2, Luiz Carlos de Lima Silveira2,3,4, Sílvia Cristina Garcia Moura-Tonello5

  • 1Pará State University, Center for Biological Sciences and Health, Belem, Pará, Brazil.

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|July 28, 2017
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Summary
This summary is machine-generated.

Multibacillary leprosy patients exhibit reduced heart rate variability (HRV), indicating increased sympathetic and decreased vagal modulation compared to healthy individuals. This suggests lower cardiac complexity and autonomic dysfunction in leprosy patients.

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Area of Science:

  • Cardiology
  • Neurology
  • Infectious Diseases

Background:

  • Leprosy, particularly the multibacillary form, can affect the autonomic nervous system.
  • Heart rate variability (HRV) analysis is a valuable tool for assessing autonomic function.
  • Understanding HRV in leprosy patients is crucial for identifying potential complications.

Purpose of the Study:

  • To evaluate heart rate variability (HRV) in patients with multibacillary leprosy.
  • To compare linear and nonlinear HRV parameters between leprosy patients and healthy controls.
  • To investigate autonomic dysfunction in leprosy using dynamic HRV analysis.

Main Methods:

  • Recruited 21 leprosy patients and 21 healthy controls.
  • Recorded HRV using a Polar RS800 CX heart monitor in supine and sitting positions.
  • Analyzed HRV using linear (frequency domain: HF, LF) and nonlinear methods (symbolic analysis, Shannon entropy, normalized complexity index).

Main Results:

  • Leprosy patients showed higher sympathetic (LF) and lower vagal (HF) modulation compared to controls.
  • Nonlinear analysis revealed reduced complexity (lower SE, NCI) and altered symbolic patterns in leprosy patients.
  • Controls exhibited significant HRV changes with position, while leprosy patients showed fewer responses.

Conclusions:

  • Leprosy patients have significantly lower HRV and cardiac modulation, indicative of autonomic dysfunction.
  • Linear and nonlinear HRV analysis effectively identifies autonomic dysfunction in multibacillary leprosy.
  • HRV assessment offers a promising non-invasive method for investigating autonomic nervous system involvement in leprosy.