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Updated: Feb 25, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Increasing age is a major risk factor for susceptibility to heat stress during physical activity
Ryan McGinn1, Martin P Poirier2, Jeffrey C Louie2
1a Human and Environmental Physiological Research Unit, Faculty of Health Sciences, University of Ottawa; Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Abstract:
We evaluated the extent to which age, cardiorespiratory fitness, and body fat can independently determine whole-body heat loss (WBHL) in 87 otherwise healthy adults. We show that increasing age is a major predictor for decreasing WBHL in otherwise healthy adults (aged 20-70 years), accounting for 40% of the variation in the largest study to date. While greater body fat also had a minor detrimental impact on WBHL, there was no significant role for cardiorespiratory fitness.
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